Available in powder or liquid form. Betulinic acid (BA), a widely distributed lupane-type triterpenoid, has been reported to possess antioxidative activity and inhibit apoptosis in MIRI. Antioxidants have been shown to support protection of the skin by reducing free radical production. For your benefits, I guess you may also be interested in the price trend of Betulinic Acid. Betulinic acid is found in birch trees but is absorbed by the mushroom as it grows on the host tree. Betulin gets its name because it is found in such high amounts in the bark of these trees. This includes species like paper birch, black birch, river birch, or yellow birch. It is reportedly very high in silver birch ( Betula pendula) especially. Birch bark has been shown to act as a laxative and diuretic, and many consume it orally to treat their gout, rheumatism and kidney stones. Betulinic Acid is widely used as nutritional supplement. While Chaga is phenomenal in its own right, many of its properties come from the natural compounds it extracts from the birch bark it lives on; Betulin and Betulinic Acid being the most notable. It is the same compound found in Chaga mushroom, considered one of those compounds responsible for Chagas outstanding health support. It is known as a natural antioxidant, anti-inflammatory, improves atopic dermatitis/eczema conditions of the skin, eliminates symptom of severe itching, stimulates collagen and elastin in the skin (lifting effect, anti-wrinkle effect). Biological Activity for Betulinic acid. The betulin and betulinic acid found in the Chaga extract can be ingested orally, which makes it particularly attractive to researchers. betulinic acid can reduce inflammation and immunostimulatory responses, Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Betulinic acid is part of the group of compounds triterpenoids, naturally occurring in birch trees, but present in many other botanical sources. betulinic acid supplements are most likely a waste of money. Oleanolic (OA), ursolic (UA), and betulinic (BA) acids are three triterpenic acids (TAs) with potential effects for treatment of type 2 diabetes (T2DM). DOI: 10.1016/j.foodchem.2012.08.011 Corpus ID: 23106073; A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. Also a GPBA receptor partial agonist (EC 50 = 1.04 M, efficacy 83%). (2012) reported a novel mechanism of action for B10, a semi-synthetic glycosylated derivative of betulinic acid. Just like most people we are occasional consumers of dietary supplements. Betulinic acid belongs to the group of pentacyclic triterpenoids and is well known for its antitumor activities. Betula Botanicals is a dietary supplement company based in Minnesota and focused on sharing the bounty of the birch tree with the rest of the world. Betulinic acid and its precursor, betulin, are mainly found in the bark of the Betula alba (white birch) tree. The bark can contain up to 35% of betulin. As a dietary supplement, adults take 2 grams (roughly 1/2 tsp) 1-2 times per day, preferably on an empty stomach. Betulinic acid is a PPAR antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis. 5. Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation Authors Hui-Zi Zhao 1 , Lin Wu 1 , Yuan Zhang 1 , Shiqi Feng 1 , Yuhao Ding 1 , Xin Deng 1 , Rui Feng 1 , Jun Li 1 , Tao-Tao Ma 2 , Cheng Huang 3 Affiliations It is widely accepted as safe additive in many countries. Birch pollen can cause allergic reactions in people with Therefore, supplement producers must consider the use of tailored extractions. It is effect on anti-oxidant.Since betulinic contains vitamins B1, B2, A, C and E, betulinic acid is also believed to work as an antioxidant capable of slowing or preventing the oxidation of other molecules. It can be used as adaptogenic, betulinic is used to refer to a natural herb product that increases the body'sresistance to stress, trauma, anxiety and fatigue. Other constituents are being investigated for a possible role in the treatment of human cancers. Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties. Oral administration of betulinic acid significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Betulinic acid (3-hydroxy-lup-20(29)-en-28-oic acid) Food supplement producers leaning towards the use of PTAs as nutraceuticals must be aware that the lipophilic behaviour of PTAs prevents them from being abundant in most commercial extracts. Betulinic acid (BA), a naturally occurring triterpenoid, is a promising compound for cancer treatment. The birch tree bark extract betulin, betulinic acid and lupeol are used as an ingredient in cosmetology for skin and hair care. More than 500 kgs 10-500 kgs Less than 10 kgs. Scientific Reports 2017, 7 (1) https://doi.org/10.1038/s41598-017-05666-6; Elmira F. Khusnutdinova, Irina E. Smirnova, Oxana B. Kazakova, Anastasiya V. Petrova, Nguyen Thi Thu Ha, Do Quoc Viet. Availability: In stock Package In fact, one of the plants chemical components, Betulinic Acid, is currently being tested as a promising cancer treatment. Introduction. Myocardial ischemia–reperfusion injury (MIRI) leads to cardiac remodeling and heart failure associated with acute myocardial infarction, which is one of the leading causes of death worldwide. Betulinic acid powder is a naturally occurring pentacyclic triterpenoid compound with anti retroviral, antitumor activities, antimalarial and anti-inflammatory effects, as well as a recently discovered anticancer agent by inhibiting topoisomerase. Free radicals damage healthy skin cells and create oxidative stress. As with all dietary supplements, please consult a qualified healthcare practitioner prior to use. Natural Vitamin Powder for sale, Quality White Birch Extract Betulinic Acid/473-98-3/Natural Betulin on sale of Shaanxi Yuanyu Biological Co., Ltd from China. why betulinic acid as a food supplement? Bioavailability of Betulinic Acid, a DIY anti-cancer supplement with an increasing popularity; Bioavailability of medicinal mushroom supplements; Potentially dangerous ingredient in popular American softdrinks; About Supplement-facts.org. Foodchem International Corporation has been supplying quality Betulinic Acid to customers all over the world for over 10 years. Each Capsule Contains 150 mg of Valuable Triterpenes Such as Betulin, Betulinic Acid, and Lupeol. Betulinic acid is a naturally occurring triterpenoid found in bark extracts, and betulinic acid and synthetic analogues exhibit a broad spectrum of pharmacologic properties including antiviral, antibacterial, anti-inflammatory, antimalarial, and anticancer activities (1, 2).Betulinic acid also inhibits growth of multiple tumors, and the large difference between the Experimental approach: HCV replicon and infectious systems were used to evaluate the anti-HCV activity of BA. Due to the low Betula Botanicals Birch Bark Extract Dietary Supplement - Box of 12 Bottles 298.00 Natural Extracts From the Outer Bark of the North American Birch Tree, Betula Papyrifera (BETULA ALBA). Proven efficacy. Background and purpose: This study was designed to evaluate the effect of betulinic acid (BA), extracted from Avicennia marina, on the replication of hepatitis C virus (HCV) and to investigate the mechanism of this BA-mediated anti-HCV activity. Gonzalez et al . Betulinic acid is a triterpenoid initially derived from the white birch tree, and has received attention because of its multiple biological activities in mammalian cells. Trumpet satinash is a tree that contains betulinic acid. Betulinic acid is believed to have possible benefits in humans. To evaluate the potential of BA as a topical therapy for EMM, its anticancer effects on primary equine melanoma cells and dermal fibroblasts and its percutaneous permeation through isolated equine skin were assessed in vitro. Betulinic Acid, CAS# 472-15-1, is a Plant extracts manufactured through plant extraction, available as White Powder . Allergic reactions. Betulinic acid supplements have also shown promise in tackling type II diabetes, fungal infections and even viruses, It is widely accepted as safe food additive in many countries. Betulinic acid is a more powerful form of betulin and is found particularly in the chaga mushroom, which creates the triterpene from betulin in birch. Studies show it has all the same benefits of betulin, but better (particularly anti-cancer, anti-tumor, and anti-HIV effects). Who Is Betula Botanicals? Betulinic acid powder anti-inflammatory and skin soothing abilities are often used to treat eczema, psoriasis and warts. Betulinic Acid is widely used as nutrition supplements. Hot Tags: betulinic acid powder, natural, factory supply, hot selling, hot sales. Common dosage levels range from 150 400 mg per day depending on the application and delivery system. Betulinic Acid, CAS# 472-15-1, is a natural ingredient isolated from Birch plant, available as white powder. Betulin and Betulinic Acid have been studied as powerful antioxidants. INTRODUCTION Triterpenoids are naturally occurring substances with a broad spectrum of beneficial effects for human health. Induces the production of reactive oxygen species (ROS) and activates NF- B. For customers who need more than 500 kgs: Please be sure to buy from us. Strong Antioxidant. Food supplement. Furthermore, betulinic acid restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). The library of about 1000 betulinic acid-derived triterpenes was collected and analyzed for cytotoxic activity on cancer Our actives can be formulated as stand-alone products or as ingredients in multifaceted supplement formulations. Betulin Caffeate. Please choose the right channel that fits your need? Trumpet satinash is used as a source of betulinic acid. The raw bark is readily available in large quantities since it is a waste product in the paper and furniture manufacturing industries. Betulinic acid can also be manufactured easily from betulin in a 2-step semi-synthetic process with a general yield of about 71%. (3beta)-. Abstract. Betulin is an all-natural, health-enhancing triterpene with lots of claimed wellness benefits to its name.